Phosphorus oxychloride → HCID 53408117、化合物
反応式
Br.[Br:2][C:3]1[CH:4]=[N:5][C:6](=O)[NH:7][CH:8]=1.P(Cl)(Cl)([Cl:12])=O>>[ClH:12].[Br:2][C:3]1[C:4]([Cl:12])=[N:5][CH:6]=[N:7][CH:8]=1参加物
3
反応条件
- 温度
- 90 °C
実験手順
A suspension of 5-bromopyrimidone hydrobromide (1.0 g, 3.9 mmol) in phosphorous oxychloride (4 mL) was heated at 90° C. for 1 h then cooled 0° C. The mixture was filtered, washed with POCl3 (2×2 mL) to furnish the title compound as a cream solid (388 mg). This compound was unstable to air and was used immediately in the next step.
後処理
- temperaturethen cooled 0° C
- filtrationThe mixture was filtered
- washwashed with POCl3 (2×2 mL)
出典と根拠
- ORDレコード
- ord-688f370ec4aa487a9a170614f2ba51b7
- 出典データセット
- uspto-grants-2014_07
- 特許番号
- US08778925B2
反応ノート
読み込み中…