関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Phosphorus oxychloride | HCID 24813 | — |
| 反応物 | 4-Pyrimidinol, 5-methyl- | HCID 205324 | — |
| 生成物 | 4-Chloro-5-methylpyrimidine hydrochloride | HCID 53407931 | — |
反応手順
A mixture of 5-methyl-3H-pyrimidin-4-one (0.60 g, 3.6 mmol) and phosphorous oxychloride (2.0 mL) was heated at 90° C. for 2.5 h. The mixture was evaporated to dryness under reduced pressure and the resultant solid was purified by sublimation under reduced pressure to furnish the title compound as a white solid. This compound was unstable to air and was used immediately in the next step.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08778925B2 |
|---|
| 出典データセット | uspto-grants-2014_07 |
|---|
| ORD ID | ord-5c6992e2e2cc4d99b61018019e5c64be |
|---|
| 出典メモ | uspto-grants-2014_07 |
|---|
