4-(Trifluoromethyl)benzhydrol → 4-(Trifluoromethyl)benzophenone

HRID 1622568

反応式

HRID 1622568 の反応式
[F:1][C:2]([F:18])([F:17])[C:3]1[CH:16]=[CH:15][C:6]([CH:7]([OH:14])[C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[CH:5][CH:4]=1>C(Cl)Cl.[O-2].[Mn+4].[O-2]>[C:8]1([C:7]([C:6]2[CH:15]=[CH:16][C:3]([C:2]([F:1])([F:17])[F:18])=[CH:4][CH:5]=2)=[O:14])[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

参加物

4

反応物 1

HCID 2588974-(Trifluoromethyl)benzhydrol

生成物 1

HCID 697674-(Trifluoromethyl)benzophenone

試薬・触媒・溶媒 2

HCID 178418406HCID 178418406、化合物触媒HCID 6344Dichloromethane溶媒

実験手順

A solution of 4-(trifluoromethyl)benzhydrol (1.836 g, 7.3 mmol) in anhydrous DCM (65 mL) was treated with manganese(IV) oxide (<5 micron, activated) (5.7 g, 66 mmol). The resulting suspension was stirred at rt for 12 days. The catalyst was removed by filtration through a Celite® brand filter agent pad. The filtrate was concentrated, and the resulting solid was dried under high vacuum to afford the title compound as a white solid.

後処理

  1. customThe catalyst was removed by filtration through a Celite® brand
  2. filtrationfilter agent pad
  3. concentrationThe filtrate was concentrated
  4. customthe resulting solid was dried under high vacuum

出典と根拠

ORDレコード
ord-9cb6e0d07be5439e89dbfee072d9e683
出典データセット
uspto-grants-2014_07
特許番号
US08778941B2

関連ノート

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