化工社化工社 化学情報印刷レポート · 研究参考用
Ethyl diazoacetate → 4-(Tert-butyl-diphenyl-silanyloxy)-bicyclo[5.1.0]octane-8-carboxylic acid ethyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethyl diazoacetate | HCID 12192 | — |
| 反応物 | Tert-butyl-(cyclohept-4-enyloxy)-diphenyl-silane | HCID 67512396 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 4-(Tert-butyl-diphenyl-silanyloxy)-bicyclo[5.1.0]octane-8-carboxylic acid ethyl ester | HCID 68688603 | — |
反応手順
To a solution of Example 8C (2.2 g, 6.28 mmoles) and Rh2(OAc)4 (2 mg, 4.3 μmol) in dichloromethane (2 mL), ethyl diazoacetate (0.717 g, 6.28 mmoles) in dichloromethane (4 mL) was added over two hours via a syringe pump. The solvent was evaporated in vacuo and product purified by flash column chromatography (hexanes:ethyl acetate 100:0 to 80:20) to provide the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07737137B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-e40caf334b0742ffaf4ef4909375fc79 |
| 出典メモ | uspto-grants-2010_06 |