Imidazole → 3-(4-((Tert-butyl(dimethyl)silyl)oxy)phenyl)pyridin-2-amine

HRID 1622741ノート

反応式

HRID 1622741 の反応式
[NH2:1][C:2]1[C:7]([C:8]2[CH:13]=[CH:12][C:11]([OH:14])=[CH:10][CH:9]=2)=[CH:6][CH:5]=[CH:4][N:3]=1.[C:15]([Si:19]([CH3:22])([CH3:21])Cl)([CH3:18])([CH3:17])[CH3:16].N1C=CN=C1.O>CN(C=O)C>[Si:19]([O:14][C:11]1[CH:12]=[CH:13][C:8]([C:7]2[C:2]([NH2:1])=[N:3][CH:4]=[CH:5][CH:6]=2)=[CH:9][CH:10]=1)([C:15]([CH3:18])([CH3:17])[CH3:16])([CH3:22])[CH3:21]

参加物

6

反応物 4

HCID 795ImidazoleHCID 962WaterHCID 28928tert-Butyldimethylsilyl chlorideHCID 667484774-(2-Aminopyridin-3-yl)phenol

生成物 1

HCID 667477073-(4-((Tert-butyl(dimethyl)silyl)oxy)phenyl)pyridin-2-amine

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

A mixture of 4-(2-aminopyridin-3-yl)phenol (19.8 g), tert-butyldimethylchlorosilane (21.8 mL) and 1H-imidazol (8.69 g) in DMF (200 mL) was stirred at room temperature for 20 hr. To the mixture was added water, and the resulting precipitate was collected by filtration, and then washed with water to give the title compound (30.5 g) as a white solid.

後処理

  1. filtrationthe resulting precipitate was collected by filtration
  2. washwashed with water

出典と根拠

ORDレコード
ord-4fbeb80586f945ee99656b49ed57d9e2
出典データセット
uspto-grants-2014_07
特許番号
US08778934B2

反応ノート

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