Hydrogen chloride-ethyl acetate → 1-(2-Aminopyridin-3-yl)-4-phenylcyclohexanol hydrochloride
反応式
[ClH:1].CCOC(C)=O.C(OC(=O)[NH:14][C:15]1[C:20]([C:21]2([OH:33])[CH2:26][CH2:25][CH:24]([C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)[CH2:23][CH2:22]2)=[CH:19][CH:18]=[CH:17][N:16]=1)(C)(C)C>>[ClH:1].[NH2:14][C:15]1[C:20]([C:21]2([OH:33])[CH2:26][CH2:25][CH:24]([C:27]3[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=3)[CH2:23][CH2:22]2)=[CH:19][CH:18]=[CH:17][N:16]=1参加物
3
実験手順
4N HCl-EtOAc (5 ml) was added to tert-butyl[3-(1-hydroxy-4-phenylcyclohexyl)pyridin-2-yl]carbamate (450 mg) and the mixture was stirred at room temperature overnight. The resulted precipitates were collected and dried in vacuo to give 1-(2-aminopyridin-3-yl)-4-phenylcyclohexanol hydrochloride.
後処理
- customThe resulted precipitates
- customwere collected
- customdried in vacuo