Trimethyl orthovalerate → HCID 12106184、化合物

HRID 1623150ノート

反応式

HRID 1623150 の反応式
[Si:1]([O:8][CH2:9][CH2:10][CH2:11][CH2:12][NH:13][C:14]1[C:23]2[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=2)[N:17]=[CH:16][C:15]=1[NH2:24])([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].[C:25](OC)(OC)(OC)[CH2:26][CH2:27][CH2:28][CH3:29]>C1(C)C=CC=CC=1>[CH2:26]([C:25]1[N:13]([CH2:12][CH2:11][CH2:10][CH2:9][O:8][Si:1]([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2])[C:14]2[C:23]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[N:17]=[CH:16][C:15]=2[N:24]=1)[CH2:27][CH2:28][CH3:29]

参加物

4

反応物 2

HCID 83755Trimethyl orthovalerateHCID 12106183HCID 12106183、化合物

生成物 1

HCID 12106184HCID 12106184、化合物

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

A solution of N4-[4-(tert-butyldimethylsilanyloxy)butyl]quinoline-3,4-diamine (62.9 g, 182 mmol) and trimethyl orthovalerate (45.2 g, 278 mmol) in toluene (200 mL) was heated at reflux for 2 hours and then concentrated under reduced pressure to provide 2-butyl-1-[4-(tert-butyldimethylsilanyloxy)butyl]-1H-imidazo[4,5-c]quinoline as an oil that was used directly in the next step without further purification.

後処理

  1. temperatureat reflux for 2 hours
  2. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-8d15b9dc0eb247b48f728e5ada5083cf
出典データセット
uspto-grants-2014_07
特許番号
US08778963B2

反応ノート

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