4-Toluenesulfonyl chloride → Methyl 2-hydroxy-5-{[(4-methylphenyl)sulfonyl]oxy}benzoate

HRID 1623656ノート

反応式

HRID 1623656 の反応式
[OH:1][C:2]1[CH:11]=[CH:10][C:9]([OH:12])=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5].C(=O)([O-])[O-].[K+].[K+].[S:19](Cl)([C:22]1[CH:28]=[CH:27][C:25]([CH3:26])=[CH:24][CH:23]=1)(=[O:21])=[O:20]>CC(C)=O>[OH:1][C:2]1[CH:11]=[CH:10][C:9]([O:12][S:19]([C:22]2[CH:28]=[CH:27][C:25]([CH3:26])=[CH:24][CH:23]=2)(=[O:21])=[O:20])=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5]

参加物

5

反応物 3

HCID 73974-Toluenesulfonyl chlorideHCID 11430Potassium CarbonateHCID 75077Methyl Gentisate

生成物 1

HCID 15727852Methyl 2-hydroxy-5-{[(4-methylphenyl)sulfonyl]oxy}benzoate

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

A mixture of methyl 2,5-dihydroxybenzoate (1.5 g, 8.92 mmol), potassium carbonate (7.50 g, 54.2 mmol), and dry acetone (100 ml) was stirred at room temperature for 30 min. To the mixture was added TsCl (1.72 g, 9.00 mmol) portionwise and the mixture was refluxed for 7 h. The reaction mixture was used in the next step directly.

後処理

  1. temperaturethe mixture was refluxed for 7 h

出典と根拠

ORDレコード
ord-84de467f8d274fb9b3a510b96ab648b3
出典データセット
uspto-grants-2014_07
特許番号
US08778939B2

反応ノート

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