Benzyl Bromide → Methyl 5-{[(4-methylphenyl)sulfonyl]oxy}-2-[(phenylmethyl)oxy]benzoate

HRID 1623657ノート

反応式

HRID 1623657 の反応式
Br[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[OH:9][C:10]1[CH:19]=[CH:18][C:17]([O:20][S:21]([C:24]2[CH:29]=[CH:28][C:27]([CH3:30])=[CH:26][CH:25]=2)(=[O:23])=[O:22])=[CH:16][C:11]=1[C:12]([O:14][CH3:15])=[O:13]>>[CH3:30][C:27]1[CH:28]=[CH:29][C:24]([S:21]([O:20][C:17]2[CH:18]=[CH:19][C:10]([O:9][CH2:2][C:3]3[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=3)=[C:11]([CH:16]=2)[C:12]([O:14][CH3:15])=[O:13])(=[O:23])=[O:22])=[CH:25][CH:26]=1

参加物

3

反応物 2

HCID 7498Benzyl BromideHCID 15727852Methyl 2-hydroxy-5-{[(4-methylphenyl)sulfonyl]oxy}benzoate

生成物 1

HCID 86762539Methyl 5-{[(4-methylphenyl)sulfonyl]oxy}-2-[(phenylmethyl)oxy]benzoate

実験手順

(Bromomethyl)benzene (3.81 g, 22.26 mmol) was added to methyl 2-hydroxy-5-{[(4-methylphenyl)sulfonyl]oxy}benzoate (may be prepared as described in Description 36; 2.87 g, 8.90 mmol) and the resulting mixture was refluxed overnight. After cooling, the resulting precipitate was filtered and the filtrate was evaporated. The crude product was purified by silica gel chromatography, eluting with a 4:1 mixture of hexane:ethyl acetate to yield the title compound as a colourless oil. 2.7 g.

後処理

  1. temperaturethe resulting mixture was refluxed overnight
  2. temperatureAfter cooling
  3. filtrationthe resulting precipitate was filtered
  4. customthe filtrate was evaporated
  5. customThe crude product was purified by silica gel chromatography
  6. washeluting with a 4:1 mixture of hexane

出典と根拠

ORDレコード
ord-d37e0a2dd1dd45afb5713aa859ab0eda
出典データセット
uspto-grants-2014_07
特許番号
US08778939B2

反応ノート

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