[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][O:9][C:10]2[CH:19]=[CH:18][C:17](I)=[CH:16][C:11]=2[C:12]([O:14][CH3:15])=[O:13])=[CH:4][CH:3]=1.C([O:23][CH:24](OCC)[CH:25]=[CH2:26])C.C(=O)([O-])[O-].[K+].[K+].Cl>CN(C)C=O>[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][O:9][C:10]2[CH:19]=[CH:18][C:17](/[CH:26]=[CH:25]\[CH:24]=[O:23])=[CH:16][C:11]=2[C:12]([O:14][CH3:15])=[O:13])=[CH:4][CH:3]=1To a suspension of methyl 2-{[(4-fluorophenyl)methyl]oxy}-5-iodobenzoate (may be prepared as described in Description 112; 740 mg, 1.92 mmol) in N,N-dimethylformamide (5 ml) was added 3,3-bis(ethyloxy)-1-propene (0.88 ml, 5.8 mmol), potassium carbonate (397 mg, 2.87 mmol) and PdOAc2 (25.8 mg, 0.115 mmol). The reaction was heated in the microwave at 120° C. for 40 minutes, cooled and then 2M HCl (5 ml) was added and the mixture stirred for 20 minutes. The mixture was extracted with diethyl ether (2×10 ml), the organic layer dried (MgSO4), and the solvent removed in vacuo. Purification by column (Si, (solute, 6:1 cyclohexane/ethyl acetate) yielded the title compound. 163 mg.
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