Hydrochloric Acid → HCID 67060892、化合物
反応式
CC(S([NH:7][C:8]1([C:12]([F:15])([F:14])[F:13])[CH2:11][O:10][CH2:9]1)=O)(C)C.[ClH:16].O1CCOCC1>CO>[ClH:16].[F:13][C:12]([F:15])([F:14])[C:8]1([NH2:7])[CH2:11][O:10][CH2:9]1参加物
5
実験手順
2-Methyl-N-(3-(trifluoromethyl)oxetan-3-yl)propane-2-sulfinamide (52 mg, 0.212 mmol) was dissolved in methanol (1 mL). The solution was cooled down at ice-water bath and added slowly 4 N HCl in dioxane (240 μL, 0.954 mmol). The mixture was warmed to room temperature, stirred for 5 h, then concentrated. The solid was washed with ether twice then dried in vacuo to give the title compound (27 mg).
後処理
- temperatureThe solution was cooled down at ice-water bath
- concentrationconcentrated
- washThe solid was washed with ether twice
- customdried in vacuo
出典と根拠
- ORDレコード
- ord-c16a79f79d9e4ea881bdbe298dd8ece0
- 出典データセット
- uspto-grants-2014_07
- 特許番号
- US08778950B2
反応ノート
読み込み中…