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Acetaldehyde → 4-ethylamino-N-(2,1,3-benzothiadiazol-5-yl)-1-benzenesulfonamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetaldehyde | HCID 177 | — |
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Sodium cyanoborohydride | HCID 5003444 | — |
| 反応物 | 4-amino-N-(2,1,3-benzothiadiazol-5-yl)-1-benzenesulfonamide | HCID 19691899 | — |
| 触媒 | Titanium Tetrachloride | HCID 24193 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 4-ethylamino-N-(2,1,3-benzothiadiazol-5-yl)-1-benzenesulfonamide | HCID 19691908 | — |
反応手順
A solution of 6 g of 4-amino-N-(2,1,3-benzothiadiazol-5-yl)-1-benzenesulfonamide and 0.5 g of titanium tetrachloride in 100 ml of methanol is treated with 1 ml of freshly distilled acetaldehyde. 4 g of sodium cyanoborohydride are then added thereto and the mixture is stirred for 30 hours. Cold half-concentrated hydrochloric acid is added thereto, the mixture is worked up in the customary manner and 4-ethylamino-N-(2,1,3-benzothiadiazol-5-yl)-1-benzenesulfonamide is obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05726194 |
| 出典データセット | uspto-grants-1998_03 |
| ORD ID | ord-a7fa891adf0d455598641c30d6e12a91 |
| 出典メモ | uspto-grants-1998_03 |