Acetic Acid → 2-Methylthieno[3,4-d][1,3]oxazole
反応式
[SH:1][CH2:2][C:3]1[N:4]=[C:5]([CH3:10])[O:6][C:7]=1[CH:8]=O.C(O)(=O)C>C(O)C>[CH3:10][C:5]1[O:6][C:7]2[C:3](=[CH:2][S:1][CH:8]=2)[N:4]=1参加物
4
反応条件
- 温度
- 80 °C
実験手順
5 mmol of 4-(mercaptomethyl)-2-methyl-1,3-oxazole-5-carbaldehyde was described in 50 ml of ethanol, then 50 mmol of acetic acid was added. Stirring was continued for 1 hour at a room temperature and the temperature was heated up to 80° C. to carry out the reaction for 4 hours. The reacted liquid was cooled down to a room temperature and the solvent was evaporated out. The product was purified using column separation with the solvents of ethylacetate and hexane, obtaining 2-methylthieno[3,4-d][1,3]oxazole.
後処理
- customthe reaction for 4 hours
- temperatureThe reacted liquid was cooled down to a room temperature
- customthe solvent was evaporated out
- customThe product was purified
- customcolumn separation with the solvents of ethylacetate and hexane
出典と根拠
- ORDレコード
- ord-fc439687ccda455b899ef4c30493c3b6
- 出典データセット
- uspto-grants-2014_07
- 特許番号
- US08779086B2
反応ノート
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