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Triethylamine → 1-Benzylpyrrolidin-3-yl methanesulfonate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Methanesulfonyl chloride | HCID 31297 | — |
| 反応物 | N-benzyl-3-pyrrolidinol | HCID 69889 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 1-Benzylpyrrolidin-3-yl methanesulfonate | HCID 9899811 | — |
反応手順
1-Benzyl-3-pyrrolidinol (1.1 g) in toluene (10 mL) at 0° C. was treated with triethylamine (1 mL) and methanesulfonyl chloride (0.53 mL), warmed to room temperature, washed with saturated aqueous sodium bicarbonate, water, and brine, dried over anhydrous sodium sulfate, and concentrated. 1H NMR (300 MHz, DMSO-d6) δ 7.31 (s, 5H), 5.21 (m, 1H), 3.65 (q, 2H), 2.82 (m, 2H), 2.5 (m, 2H), 2.36 (m, 2H), 2.1 (m, 1H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07737159B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-6aba10ad0d9e4fbfb043799c04450e0e |
| 出典メモ | uspto-grants-2010_06 |