Triethylamine → 1-Benzylpyrrolidin-3-yl methanesulfonate

HRID 16243

反応式

HRID 16243 の反応式
[CH2:1]([N:8]1[CH2:12][CH2:11][CH:10]([OH:13])[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(N(CC)CC)C.[CH3:21][S:22](Cl)(=[O:24])=[O:23]>C1(C)C=CC=CC=1>[CH3:21][S:22]([O:13][CH:10]1[CH2:11][CH2:12][N:8]([CH2:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)[CH2:9]1)(=[O:24])=[O:23]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 69889N-benzyl-3-pyrrolidinol

生成物 1

HCID 98998111-Benzylpyrrolidin-3-yl methanesulfonate

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

1-Benzyl-3-pyrrolidinol (1.1 g) in toluene (10 mL) at 0° C. was treated with triethylamine (1 mL) and methanesulfonyl chloride (0.53 mL), warmed to room temperature, washed with saturated aqueous sodium bicarbonate, water, and brine, dried over anhydrous sodium sulfate, and concentrated. 1H NMR (300 MHz, DMSO-d6) δ 7.31 (s, 5H), 5.21 (m, 1H), 3.65 (q, 2H), 2.82 (m, 2H), 2.5 (m, 2H), 2.36 (m, 2H), 2.1 (m, 1H).

後処理

  1. washwashed with saturated aqueous sodium bicarbonate, water, and brine
  2. dry with materialdried over anhydrous sodium sulfate
  3. concentrationconcentrated

出典と根拠

ORDレコード
ord-6aba10ad0d9e4fbfb043799c04450e0e
出典データセット
uspto-grants-2010_06
特許番号
US07737159B2

関連ノート

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