Potassium Cyanide → [5-(4-Bromo-phenyl)-3-methyl-isoxazol-4-yl]acetonitrile

HRID 1624380ノート

反応式

HRID 1624380 の反応式
Br[CH2:2][C:3]1[C:4]([CH3:15])=[N:5][O:6][C:7]=1[C:8]1[CH:13]=[CH:12][C:11]([Br:14])=[CH:10][CH:9]=1.[C-:16]#[N:17].[K+]>CN(C=O)C>[Br:14][C:11]1[CH:12]=[CH:13][C:8]([C:7]2[O:6][N:5]=[C:4]([CH3:15])[C:3]=2[CH2:2][C:16]#[N:17])=[CH:9][CH:10]=1

参加物

4

反応物 2

HCID 9032Potassium CyanideHCID 665772234-Bromomethyl-5-(4-bromo-phenyl)-3-methyl-isoxazole

生成物 1

HCID 66577425[5-(4-Bromo-phenyl)-3-methyl-isoxazol-4-yl]acetonitrile

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
65 °C

実験手順

To 4-bromomethyl-5-(4-bromo-phenyl)-3-methyl-isoxazole (10.74 mmol) in DMF (30 mL) was added potassium cyanide (0.729 g, 10.74 mmol), and the reaction was stirred at 65° C. overnight. After aqueous workup, the crude material was purified by silica gel chromatography (0-70% EtOAc in hexanes) to give the title compound.

後処理

  1. customAfter aqueous workup, the crude material was purified by silica gel chromatography (0-70% EtOAc in hexanes)

出典と根拠

ORDレコード
ord-d4dc7375347a4f8299cb54282d6b5f01
出典データセット
uspto-grants-2014_07
特許番号
US08778983B2

反応ノート

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