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Acetonitrile → 1-Benzylpyrrolidine-3-carbonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetonitrile | HCID 6342 | — |
| 反応物 | Sodium Bicarbonate | HCID 516892 | — |
| 反応物 | 1-Benzylpyrrolidin-3-yl methanesulfonate | HCID 9899811 | — |
| 触媒 | Tetrabutylammonium Cyanide | HCID 165872 | — |
| 生成物 | 1-Benzylpyrrolidine-3-carbonitrile | HCID 4674579 | — |
反応手順
A mixture of EXAMPLE 1G (1.5 g) and tetrabutlyammonium cyanide (3.15 gm) in acetonitrile (25 mL) was heated at 65° C. for 24 hours, poured into saturated aqueous sodium bicarbonate, and extracted with toluene. The extract was washed with distilled water, dried over anhydrous sodium sulfate, and concentrated. 1H NMR (300 MHz, CDCl3) δ 7.33 (s, 5H), 3.42 (m, 2H), 2.89 (m, 1H), 2.72 (m, 1H), 1.68 (b, 3H), 1.45 (m, 2H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07737159B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-0f73c1e849cc445a98e72179d7bd2338 |
| 出典メモ | uspto-grants-2010_06 |