関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Anisole | HCID 7519 | — |
| 反応物 | 1h-Pyrazole-3-carboxamide,4-[3-(hydroxymethyl)phenyl]-1-[(4-methoxyphenyl)methyl]-n-phenyl- | HCID 66855422 | — |
| 溶媒 | Trifluoroacetic acid | HCID 6422 | — |
| 生成物 | HCID 178521930 | HCID 178521930 | 35.2% |
反応手順
A mixture of 4-(3-hydroxymethyl-phenyl)-1-(4-methoxy-benzyl)-1H-pyrazole-3-carboxylic acid phenylamide (20 mg) and anisole (20 μl) in trifluoroacetic acid (1 ml) was heated at 120° C. (50 W) for 15 minutes in a CEM Discover microwave synthesiser. The reaction was evaporated then purified by flash column chromatography eluting with 2:1 ethyl acetate/hexane. Product containing fractions were combined and evaporated to give 5 mg of product. (LC/MS: Rt 2.55 [M+H]+ 294).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08779147B2 |
|---|
| 出典データセット | uspto-grants-2014_07 |
|---|
| ORD ID | ord-529d16975e5a490e9147b911c08f97c0 |
|---|
| 出典メモ | uspto-grants-2014_07 |
|---|
