4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenol → 4-{6-[(3,4,5-Trimethoxyphenyl)amino]pyrazin-2-yl}phenol

HRID 16250

反応式

HRID 16250 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([NH:13][C:14]2[CH:19]=[N:18][CH:17]=[C:16](Cl)[N:15]=2)[CH:6]=[C:7]([O:11][CH3:12])[C:8]=1[O:9][CH3:10].B1([C:30]2[CH:35]=[CH:34][C:33]([OH:36])=[CH:32][CH:31]=2)OC(C)(C)C(C)(C)O1>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([NH:13][C:14]2[CH:19]=[N:18][CH:17]=[C:16]([C:30]3[CH:35]=[CH:34][C:33]([OH:36])=[CH:32][CH:31]=3)[N:15]=2)[CH:6]=[C:7]([O:11][CH3:12])[C:8]=1[O:9][CH3:10]

参加物

3

反応物 2

HCID 27346244-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenolHCID 116090492-(3,4,5-Trimethoxyphenylamino)-6-chloropyrazine

生成物 1

HCID 1354530734-{6-[(3,4,5-Trimethoxyphenyl)amino]pyrazin-2-yl}phenol収率 59.7%

実験手順

Using Method B with 275 mg (0.93 mmol) 2a and 242 mg (1.10 mmol) 4-(4,4,5,5-tetramethyl-1,3,2-dioxoborolan-2-yl)phenol, 83 mg pure title compound (59.7%) were obtained after purification by preparative HPLC (eluent:AcOEt). Reaction time: 48 hours.

出典と根拠

ORDレコード
ord-4a87b0a24faa4978b9e913d43971f731
出典データセット
uspto-grants-2010_06
特許番号
US07737152B2

関連ノート

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