Bromine → 2-Bromo-1-(4'-bromo-1,1'-biphenyl-4-yl)ethanone

HRID 1625490

反応式

HRID 1625490 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([C:14](=[O:16])[CH3:15])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.[Br:17]Br>C(Cl)Cl>[Br:17][CH2:15][C:14]([C:11]1[CH:12]=[CH:13][C:8]([C:5]2[CH:4]=[CH:3][C:2]([Br:1])=[CH:7][CH:6]=2)=[CH:9][CH:10]=1)=[O:16]

参加物

4

反応物 2

HCID 24408BromineHCID 798061-(4'-Bromo(1,1'-biphenyl)-4-yl)ethan-1-one

生成物 1

HCID 32747482-Bromo-1-(4'-bromo-1,1'-biphenyl-4-yl)ethanone収率 88.6%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

To a solution of 1-[4-(4-bromophenyl)phenyl]ethanone (5 g, 18.17 mmol) in CH2Cl2 (40 mL) is added bromine (983 μL, 19 mmol). The resulting mixture is stirred for 48 hours at room temperature. The mixture is diluted with dichloromethane, washed with saturated aqueous sodium bicarbonate, water, brine, dried over anhydrous sodium sulfate and concentrated. The crude solid is triturated with ether to give 2-bromo-1-[4-(4-bromophenyl)phenyl]ethanone (5.7 g, 88.6%) as a white solid.

後処理

  1. washwashed with saturated aqueous sodium bicarbonate, water, brine
  2. dry with materialdried over anhydrous sodium sulfate
  3. concentrationconcentrated
  4. customThe crude solid is triturated with ether

出典と根拠

ORDレコード
ord-56e3e94580c14036b2fa6cd417fff457
出典データセット
uspto-grants-2014_07
特許番号
US08779156B2

関連ノート

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