Methanesulfonate → Neramexane Mesylate

反応式

[NH2:1][C:2]1([CH3:12])[CH2:7][C:6]([CH3:9])([CH3:8])[CH2:5][C:4]([CH3:11])([CH3:10])[CH2:3]1.[S:13]([O-:17])(=[O:16])(=[O:15])[CH3:14]>>[S:13]([OH:17])(=[O:16])(=[O:15])[CH3:14].[NH2:1][C:2]1([CH3:12])[CH2:7][C:6]([CH3:9])([CH3:8])[CH2:5][C:4]([CH3:11])([CH3:10])[CH2:3]1

参加物

反応物 2

HCID 85257Methanesulfonate

HCID 6433106Neramexane

生成物 1

HCID 11425584Neramexane Mesylate

実験手順

In one embodiment, crude 1-amino-1,3,3,5,5-pentamethylcyclohexane comprising 1-amino-1,3,3-trans-5-tetramethylcyclohexane is subjected to mesylate formation according to the process of the invention, wherein 1-amino-1,3,3,5,5-pentamethylcyclohexane mesylate is formed comprising 1-amino-1,3,3-trans-5-tetramethylcyclohexane mesylate.

出典と根拠

ORDレコード: ord-735117ee4ae248a6b6c3f6ea931c023e
出典データセット: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08784847B2

反応ノート

読み込み中…