Ammonium Hydroxide → (S)-2-amino-6-(3-oxocyclobutanecarboxamido)hexanoic acid
反応式
[NH2:1][C@@H:2]([CH2:7][CH2:8][CH2:9][CH2:10][NH:11][C:12]([CH:14]1[CH2:17][C:16](=[O:18])[CH2:15]1)=[O:13])[C:3]([O:5]C)=[O:4].[NH4+].[OH-]>O>[NH2:1][C@@H:2]([CH2:7][CH2:8][CH2:9][CH2:10][NH:11][C:12]([CH:14]1[CH2:17][C:16](=[O:18])[CH2:15]1)=[O:13])[C:3]([OH:5])=[O:4]参加物
4
実験手順
(S)-methyl 2-amino-6-(3-oxocyclobutanecarboxamido)hexanoate (0.297 g) and 18 mL H2O were put in a 40 mL glass vial. To the resulting clear solution was added 2.2 mL 1N NH4OH, and the reaction was shaken at ambient temperature for 22 hours, at which time the LCMS analysis revealed a complete reaction. The reaction mixture was frozen and lyophilized, affording (S)-2-amino-6-(3-oxocyclobutanecarboxamido)hexanoic acid (TU3205-030) as colorless crystals. MS (ESI+): m/z 243.20 (MH+).