2-Phenylthiophene → 5-Bromo-2-trifluoromethylphenyl 5-phenyl-2-thienyl ketone

反応式

[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:11]([F:14])([F:13])[F:12])=[C:6]([CH:10]=1)[C:7]([OH:9])=O.[C:15]1([C:21]2[S:22][CH:23]=[CH:24][CH:25]=2)[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>>[C:15]1([C:21]2[S:22][C:23]([C:7]([C:6]3[CH:10]=[C:2]([Br:1])[CH:3]=[CH:4][C:5]=3[C:11]([F:14])([F:13])[F:12])=[O:9])=[CH:24][CH:25]=2)[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

参加物

反応物 2

HCID 699992-Phenylthiophene

HCID 509981405-Bromo-2-trifluoromethylbenzoic acid

生成物 1

HCID 666089255-Bromo-2-trifluoromethylphenyl 5-phenyl-2-thienyl ketone

実験手順

The above 5-bromo-2-trifluoromethylbenzoic acid and 2-phenylthiophene were treated in a manner similar to Reference Example 5-(1) to give 5-bromo-2-trifluoromethylphenyl 5-phenyl-2-thienyl ketone as pale yellow crystals. APCI-Mass m/Z 411/413 (M+H).

出典と根拠

ORDレコード: ord-d53463445d1c46e593e05f52ac3719fa
出典データセット: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08785403B2

反応ノート

読み込み中…