Potassium Carbonate → 2-(4-(4-(2,3-Dimethylphenyl)piperazin-1-yl)-3-hydroxybutyl)isoindoline-1,3-dione

HRID 1626308

反応式

HRID 1626308 の反応式
[O:1]1[CH2:3][CH:2]1[CH2:4][CH2:5][N:6]1[C:14](=[O:15])[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[C:7]1=[O:16].C(=O)([O-])[O-].[K+].[K+].Cl.[CH3:24][C:25]1[C:30]([CH3:31])=[CH:29][CH:28]=[CH:27][C:26]=1[N:32]1[CH2:37][CH2:36][NH:35][CH2:34][CH2:33]1>CN(C)C=O>[CH3:24][C:25]1[C:30]([CH3:31])=[CH:29][CH:28]=[CH:27][C:26]=1[N:32]1[CH2:33][CH2:34][N:35]([CH2:3][CH:2]([OH:1])[CH2:4][CH2:5][N:6]2[C:14](=[O:15])[C:13]3[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=3)[C:7]2=[O:16])[CH2:36][CH2:37]1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 3394332-[2-(oxiran-2-yl)ethyl]-2,3-dihydro-1H-isoindole-1,3-dioneHCID 130346471-(2,3-Dimethylphenyl)piperazine hydrochloride

生成物 1

HCID 672050722-(4-(4-(2,3-Dimethylphenyl)piperazin-1-yl)-3-hydroxybutyl)isoindoline-1,3-dione収率 46.2%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
110 °C

実験手順

To a mixture of 2-(2-(oxiran-2-yl)ethyl)isoindoline-1,3-dione obtained in step 2 (0.30 g, 1.38 mmol) and potassium carbonate (0.48 g, 3.45 mmol) in N,N-dimethylformamide (3.0 ml), was added 1-(2,3-dimethylphenyl)piperazine hydrochloride (0.31 g, 1.38 mmol) at room temperature. The resulting reaction mixture was stirred at 110° C. for 18 hours. After the reaction complete, the reaction mixture thus obtained was filtered through a plug of Celite. The filtrate was concentrated under reduced pressure to obtain the title compound (0.26 g). The compound was used for the next step without further purification.

後処理

  1. customThe resulting reaction mixture
  2. customAfter the reaction complete, the reaction mixture thus obtained
  3. filtrationwas filtered through a plug of Celite
  4. concentrationThe filtrate was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-efd2fed5268e435e9d7457c3c1ed6d7f
出典データセット
uspto-grants-2014_07
特許番号
US08785453B2

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