Methylamine → 4-(4-(2,3-Dimethylphenyl)piperazin-1-yl)-1-(methylamino)butan-2-ol
反応式
[CH3:1][C:2]1[C:7]([CH3:8])=[CH:6][CH:5]=[CH:4][C:3]=1[N:9]1[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH:17]2[CH2:19][O:18]2)[CH2:11][CH2:10]1.[CH3:20][NH2:21]>C(O)C>[CH3:1][C:2]1[C:7]([CH3:8])=[CH:6][CH:5]=[CH:4][C:3]=1[N:9]1[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH:17]([OH:18])[CH2:19][NH:21][CH3:20])[CH2:11][CH2:10]1参加物
4
反応条件
- 温度
- 90 °C
実験手順
A mixture of 1-(2,3-dimethylphenyl)-4-(2-(oxiran-2-yl)ethyl)piperazine obtained in step 2 (0.10 g, 0.38 mmol) and methylamine (8.0 M) in ethanol (1.0 ml) was stirred at 90° C. for 20 hours. After the reaction complete, the resulting reaction mixture was concentrated under reduced pressure to obtain the title compound (0.10 g). The compound was used for the next step without further purification.