Phosphorus oxychloride → HCID 86046565、化合物
反応式
[C:1]1([C:7]2[N:8]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[C:9]3[N:10]=[CH:11][NH:12][C:13](=O)[C:14]=3[N:15]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.O=P(Cl)(Cl)[Cl:25]>>[Cl:25][C:13]1[N:12]=[CH:11][N:10]=[C:9]2[C:14]=1[N:15]=[C:7]([C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)[N:8]2[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1参加物
3
反応条件
- 温度
- 110 °C
実験手順
8,9-diphenyl-1H-purin-6(9H)-one obtained in step 3 (22.3 g, 77.4 mmol) was dissolved in POCl3 (70 ml) at 0° C. and the reaction mixture was heated to reflux at 110° C. overnight. After cooled to room temperature, ice-water was added to the resulting reaction mixture and stirred for 30 min at room temperature. The resulting mixture was filtered with water. The collected solid was dried under reduced pressure to obtain the title compound (20 g, 84%) as beige solid.
後処理
- temperaturethe reaction mixture was heated
- temperature