Hydrochloride methanol → 1260081-87-5

HRID 1626329ノート

反応式

HRID 1626329 の反応式
CO.Cl.[N:4]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][C:12]=2[S:14]([NH:17][C:18]2[CH:38]=[CH:37][C:21]([C:22]([N:24]3[CH2:29][CH2:28][N:27](C(OC(C)(C)C)=O)[CH2:26][CH2:25]3)=[O:23])=[CH:20][CH:19]=2)(=[O:16])=[O:15])[CH:7]=[CH:6][CH:5]=1>>[N:24]1([C:22]([C:21]2[CH:20]=[CH:19][C:18]([NH:17][S:14]([C:12]3[CH:11]=[CH:10][CH:9]=[C:8]4[C:13]=3[N:4]=[CH:5][CH:6]=[CH:7]4)(=[O:16])=[O:15])=[CH:38][CH:37]=2)=[O:23])[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]1

参加物

3

反応物 2

HCID 21893726Hydrochloride methanolHCID 59634969HCID 59634969、化合物

生成物 1

HCID 596349121260081-87-5収率 94.3%

実験手順

To a solution of MeOH.HCl, Boc protected amine 138 (2 gm, 4.03 mmol) was added and the resulting mixture was stirred for 1 hr. After completion of reaction, solvent was removed under reduced pressure, washed with water followed by addition of NaHCO3 and extracted with DCM. The organic layer was dried over Na2SO4 and evaporated under reduced pressure to afford product 139 (1.5 gm, 94.30% yield).

後処理

  1. additionwas added
  2. customAfter completion of reaction, solvent
  3. customwas removed under reduced pressure
  4. washwashed with water
  5. additionfollowed by addition of NaHCO3
  6. extractionextracted with DCM
  7. dry with materialThe organic layer was dried over Na2SO4
  8. customevaporated under reduced pressure

出典と根拠

ORDレコード
ord-0363432c785a43418848cd69490da63a
出典データセット
uspto-grants-2014_07
特許番号
US08785450B2

反応ノート

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