Cyclobutylamine → (S)-1-cyclobutyl-3-(4-(6-methyl-4-(3-methylmorpholino)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-yl)phenyl)urea
反応式
[CH3:1][N:2]1[CH2:10][C:9]2[C:8]([N:11]3[CH2:16][CH2:15][O:14][CH2:13][C@@H:12]3[CH3:17])=[N:7][C:6]([C:18]3[CH:23]=[CH:22][C:21]([NH:24][C:25](=O)[O:26]C4C=CC=CC=4)=[CH:20][CH:19]=3)=[N:5][C:4]=2[CH2:3]1.[CH:34]1([NH2:38])[CH2:37][CH2:36][CH2:35]1>>[CH:34]1([NH:38][C:25]([NH:24][C:21]2[CH:20]=[CH:19][C:18]([C:6]3[N:7]=[C:8]([N:11]4[CH2:16][CH2:15][O:14][CH2:13][C@@H:12]4[CH3:17])[C:9]4[CH2:10][N:2]([CH3:1])[CH2:3][C:4]=4[N:5]=3)=[CH:23][CH:22]=2)=[O:26])[CH2:37][CH2:36][CH2:35]1参加物
3
実験手順
Method as described for example 51 using intermediate 10 and cyclobutanamine as starting materials. Purified by prep. LCMS (high pH).
後処理
- customPurified by prep