(R)-1-cyclopropyl-3-(3-fluoro-4-(4-(3-methylmorpholino)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-yl)phenyl)urea hydrochloride → 1-Ethyl-3-(3-fluoro-4-(4-morpholino-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-yl)phenyl)urea hydrochloride
反応式
[ClH:1].[CH:2]1([NH:5][C:6]([NH:8][C:9]2[CH:14]=[CH:13][C:12]([C:15]3[N:16]=[C:17]([N:24]4[CH2:29][CH2:28][O:27][CH2:26][C@H:25]4C)[C:18]4[CH2:23][NH:22][CH2:21][C:19]=4[N:20]=3)=[C:11]([F:31])[CH:10]=2)=[O:7])C[CH2:3]1.C(NC(=O)NC1C=CC(C2N=C(N3CCOCC3)C3CN(C(OC(C)(C)C)=O)CC=3N=2)=C(F)C=1)C>>[ClH:1].[CH2:2]([NH:5][C:6]([NH:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[N:16]=[C:17]([N:24]3[CH2:25][CH2:26][O:27][CH2:28][CH2:29]3)[C:18]3[CH2:23][NH:22][CH2:21][C:19]=3[N:20]=2)=[C:11]([F:31])[CH:10]=1)=[O:7])[CH3:3]参加物
3
反応物 2
生成物 1
実験手順
Method as described for (R)-1-cyclopropyl-3-(3-fluoro-4-(4-(3-methylmorpholino)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-yl)phenyl)urea hydrochloride (intermediate 33) step 3 tert-butyl 2-(4-(3-ethylureido)-2-fluorophenyl)-4-morpholino-5H-pyrrolo[3,4-d]pyrimidine-6(7H)-carboxylate (example 145). The resulting solid was triturated from methanol/ether to give a cream solid (60% yield).