化工社化工社 化学情報印刷レポート · 研究参考用
Chloroacetyl chloride → 5-Chloro-2-((2-chloroacetyl)amino)benzoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Chloroacetyl chloride | HCID 6577 | — |
| 反応物 | 2-Amino-5-chlorobenzoic acid | HCID 12476 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 5-Chloro-2-((2-chloroacetyl)amino)benzoic acid | HCID 4179825 | 96% |
反応手順
3.0 g (17.5 mmol) of 2-amino-5-chlorobenzoic acid and 3.95 g (35.0 mmol) of chloroacetyl chloride were heated under reflux in 60 mL of toluene for 1 hour. Thereafter, the solvent was distilled off under reduced pressure, and H2O was added to the resulting residue. Solids were collected by filtration to give 4.15 g of 5-chloro-2-[(chloroacetyl)amino]benzoic acid (yield: 96%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08785473B2 |
| 出典データセット | uspto-grants-2014_07 |
| ORD ID | ord-bf9d4edb664044ad9b7d31130bcf1dd9 |
| 出典メモ | uspto-grants-2014_07 |