Sodium Chloride → 4-[(5-Nitro-thien-2-yl)ethynyl]benzonitrile

HRID 1627

反応式

HRID 1627 の反応式
[C:1]([C:3]1[CH:10]=[CH:9][C:6]([C:7]#[N:8])=[CH:5][CH:4]=1)#[CH:2].Br[C:12]1[S:13][C:14]([N+:17]([O-:19])=[O:18])=[CH:15][CH:16]=1.C(N(CC)CC)C.[Cl-].[Na+]>CN(C)C=O.Cl[Pd](Cl)([P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)[P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1.C(OCC)(=O)C>[N+:17]([C:14]1[S:13][C:12]([C:2]#[C:1][C:3]2[CH:10]=[CH:9][C:6]([C:7]#[N:8])=[CH:5][CH:4]=2)=[CH:16][CH:15]=1)([O-:19])=[O:18]

参加物

8

反応物 4

HCID 5234Sodium ChlorideHCID 8471TriethylamineHCID 832222-Bromo-5-nitrothiopheneHCID 45472454-Ethynylbenzonitrile

生成物 1

HCID 196919534-[(5-Nitro-thien-2-yl)ethynyl]benzonitrile

試薬・触媒・溶媒 3

HCID 178418476HCID 178418476、化合物触媒HCID 6228Dimethylformamide溶媒HCID 8857Ethyl Acetate溶媒

実験手順

To a solution of 4-ethynylbenzonitrile (0.5 g), 2-bromo-5-nitrothiophene (0.9 g) and bis(triphenylphosphine)palladium dichloride (83 mg) in anhydrous dimethylformamide (4 ml) was added triethylamine (2.2 ml). The reaction mixture was stirred at room temperature for 3 days then ethyl acetate (200 ml) and saturated sodium chloride (200 ml) were added. The organic layer was dried over anhydrous sodium sulfate, filtered and evaporated to dryness. The crude solid was triturated with 1:1 dichloromethane/hexane followed by diethyl ether to give 4-[(5-nitro-2-thienyl)ethynyl]benzonitrile as a yellow solid.

後処理

  1. dry with materialThe organic layer was dried over anhydrous sodium sulfate
  2. filtrationfiltered
  3. customevaporated to dryness
  4. customThe crude solid was triturated with 1:1 dichloromethane/hexane

出典と根拠

ORDレコード
ord-f537d62089cd4cba9bc833054c2f705b
出典データセット
uspto-grants-1998_03
特許番号
US05726195

関連ノート

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