Diethyl Ether → HCID 178510511、化合物
反応式
[NH2:1][C:2]1[N:9]=[CH:8][CH:7]=[C:6]([O:10]C)[C:3]=1[C:4]#[N:5].Br[CH:13]([CH2:16][C:17]([F:20])([F:19])[F:18])[CH:14]=O.CCOCC>CCO>[OH:10][C:6]1[CH:7]=[CH:8][N:9]2[C:13]([CH2:16][C:17]([F:20])([F:19])[F:18])=[CH:14][N:1]=[C:2]2[C:3]=1[C:4]#[N:5]参加物
5
反応条件
- 温度
- 150 °C
実験手順
A mixture of compounds D3 (3.31 g, 22.19 mmol) and D8 (6.2 g, 21.86 mmol, 72% purity, calculated by 1H-NMR) in EtOH (10 ml) was subjected to microwave heating at 150° C. for 40 min. After cooling to room temperature, the solvent was evaporated in vacuo. The residue thus obtained was treated with Et2O and a solid precipitated out. The solid thus obtained was filtered off, washed with EtOAc and dried in vacuo to yield compound D9 (1 g, 18%).
後処理
- temperatureAfter cooling to room temperature
- customthe solvent was evaporated in vacuo
- customThe residue thus obtained
- customa solid precipitated out
- customThe solid thus obtained
- filtrationwas filtered off
- washwashed with EtOAc
- customdried in vacuo
出典と根拠
- ORDレコード
- ord-8e516c843cee4630b7caf54667189512
- 出典データセット
- uspto-grants-2014_07
- 特許番号
- US08785486B2
反応ノート
読み込み中…