化工社化工社 化学情報印刷レポート · 研究参考用
Dimethylformamide → (1R,4aR)-1,4a-dimethyl-7-(propan-2-yl)-1,2,3,4,4a,4b,5,6,7,10a-decahydrophenanthrene-1-carbonyl chloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | Phosphorus trichloride | HCID 24387 | — |
| 反応物 | Dihydroabietic acid | HCID 227277 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | (1R,4aR)-1,4a-dimethyl-7-(propan-2-yl)-1,2,3,4,4a,4b,5,6,7,10a-decahydrophenanthrene-1-carbonyl chloride | HCID 88415966 | 93.3% |
反応手順
A mixture of dihydroabietic acid (1.0 eq. 9.95 mmol), phosphorous (III) chloride (1.1 eq. 10.95 mmol) and DMF (0.1 ml) is refluxed overnight in THF (20 ml). The reaction mass is filtered under suction and concentrated under vacuum to give 2.98 g (93%) yellow oil. The compound is used immediately for the next step without any purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08785502B2 |
| 出典データセット | uspto-grants-2014_07 |
| ORD ID | ord-56121c6b026d4937a41bbe65d50eda61 |
| 出典メモ | uspto-grants-2014_07 |