3-(Benzyloxy)-5-phenylpyridin-2-amine → 2-Amino-5-phenylpyridin-3-ol
反応式
C([O:8][C:9]1[C:10]([NH2:21])=[N:11][CH:12]=[C:13]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH:14]=1)C1C=CC=CC=1>CO>[NH2:21][C:10]1[C:9]([OH:8])=[CH:14][C:13]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[CH:12][N:11]=1参加物
3
実験手順
To a solution of 3-benzyloxy-5-phenyl-pyridin-2-ylamine (Example I-87, 3.27 g, 11.8 mmol) in methanol (30 mL) was added Pd(CH)2 (2.5 g, 2.37 mmol). The mixture was degassed and charged with hydrogen three times, and then stirred under hydrogen balloon for 5 h. The reaction was filtered through a celite pad, washed with methanol, and condensed. After high vacuum dry, 2-amino-5-phenyl-pyridin-3-ol was obtained (2.04 g, 93% yield). MS m/z 187 [M+1].
後処理
- customThe mixture was degassed
- additioncharged with hydrogen three times
- filtrationThe reaction was filtered through a celite pad
- washwashed with methanol, and condensed
- customAfter high vacuum dry
出典と根拠
- ORDレコード
- ord-d109a0a479a648d58b7585966dfe398d
- 出典データセット
- uspto-grants-2014_07
- 特許番号
- US08785632B2
反応ノート
読み込み中…