N,N-Dimethylglycine → 1-[4-(4-{5-Amino-6-[(R)-1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyrazin-2-yl}-pyrazol-1-yl)-piperidin-1-yl]-2-dimethylamino-ethanone

反応式

[Cl:1][C:2]1[C:7]([F:8])=[CH:6][CH:5]=[C:4]([Cl:9])[C:3]=1[C@H:10]([O:12][C:13]1[C:14]([NH2:30])=[N:15][CH:16]=[C:17]([C:19]2[CH:20]=[N:21][N:22]([CH:24]3[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]3)[CH:23]=2)[N:18]=1)[CH3:11].[CH3:31][N:32]([CH2:34][C:35](O)=[O:36])[CH3:33].C1C=CC2N(O)N=NC=2C=1.C(Cl)CCl.C(N(CC)CC)C.BrC1N=C(O[C@@H](C2C(Cl)=CC=C(F)C=2Cl)C)C(N)=NC=1>CN(C=O)C>[NH2:30][C:14]1[N:15]=[CH:16][C:17]([C:19]2[CH:20]=[N:21][N:22]([CH:24]3[CH2:29][CH2:28][N:27]([C:35](=[O:36])[CH2:34][N:32]([CH3:33])[CH3:31])[CH2:26][CH2:25]3)[CH:23]=2)=[N:18][C:13]=1[O:12][C@@H:10]([C:3]1[C:4]([Cl:9])=[CH:5][CH:6]=[C:7]([F:8])[C:2]=1[Cl:1])[CH3:11]