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Ethyl Acetate → 2-Chloro-6-(2-fluorophenyl-oxy)-pyrazine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethyl Acetate | HCID 8857 | — |
| 反応物 | 2-Fluorophenol | HCID 9707 | — |
| 反応物 | 2,6-Dichloropyrazine | HCID 78504 | — |
| 溶媒 | Cyclohexane | HCID 8078 | — |
| 生成物 | 2-Chloro-6-(2-fluorophenyl-oxy)-pyrazine | HCID 59343498 | 80% |
反応手順
Using Method DD with 2,6-dichloropyrazine (250 mg, 1.69 mmol) and 2-fluorophenol (166 μL, 1.86 mmol, d=1.26 g/mL), and purification by column chromatography (AcOEt:cyclohexane, 1:1), the title compound was obtained (302 mg). Yield: 80%. 1H NMR (250 MHz, DMSO-d8) δ 7.31-7.45 (m, 4H, Harom), 8.56 (s, 1H, HPz 5), 8.67 (s, 1H, HPz 3).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07737152B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-84f417115a524c49a82fcdcb077d715b |
| 出典メモ | uspto-grants-2010_06 |