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3-Chlorophenol → 2-Chloro-6-(3-chlorophenyl-oxy)-pyrazine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Chlorophenol | HCID 7933 | — |
| 反応物 | Ethyl Acetate | HCID 8857 | — |
| 反応物 | 2,6-Dichloropyrazine | HCID 78504 | — |
| 溶媒 | Cyclohexane | HCID 8078 | — |
| 生成物 | 2-Chloro-6-(3-chlorophenyl-oxy)-pyrazine | HCID 20287998 | 85% |
反応手順
Using Method DD with 2,6-dichloropyrazine (250 mg, 1.69 mmol) and 3-chlorophenol (193 μL, 1.86 mmol, d=1.24 g/mL), and purification by column chromatography (AcOEt:cyclohexane, 1:1), the title compound was obtained (346 mg). Yield: 85%. 1H NMR (250 MHz, DMSO-d6) δ 7.32 (dd, 1H, Harom 4, Jo=8.2 Hz, Jm=1.9 Hz), 7.43 (d, 1H, Harom 6, J=8.0 Hz), 7.50 (d, 1H, Harom 2, Jm=1.9 Hz), 7.56 (t, 1H, Harom 5, J=8.1 Hz), 8.59 (s, 1H, HPz 5), 8.62 (s, 1H, HPz 3). m/z: 241.1 [(M+H)+, calcd for C10H6Cl2N2O 240.0].
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07737152B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-133c1a5c2ec548809336e842237d8715 |
| 出典メモ | uspto-grants-2010_06 |