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3-Phenylphenol → 2-Chloro-6-(3-phenyl-phenyl-oxy)-pyrazine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Phenylphenol | HCID 11381 | — |
| 反応物 | 2,6-Dichloropyrazine | HCID 78504 | — |
| 溶媒 | Cyclohexane | HCID 8078 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | 2-Chloro-6-(3-phenyl-phenyl-oxy)-pyrazine | HCID 59343501 | 98% |
反応手順
Using Method DD (reaction time: 20 hours) with 2,6-dichloropyrazine (200 mg, 1.34 mmol) and 3-phenyl-phenol (268 mg, 1.49 mmol), and purification by column chromatography (AcOEt:cyclohexane, 1:2), the title compound was obtained (370 mg). Yield: 98%. 1H NMR (250 MHz, DMSO-d6) δ 7.35-7.72 (m, 9H, Harom), 8.53 (s, 1H, HPz 5), 8.59 (s, 1H, HPz 3). m/z: 283.1 [(M+H)+, calcd for C16H11ClN2O 282.1].
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07737152B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-972732bdf86442079eb9f350a6bbc995 |
| 出典メモ | uspto-grants-2010_06 |