Methylhydrazine → HCID 86664828、化合物

反応式

[Cl:1][C:2]1[CH:7]=[C:6]([C:8]2[CH:12]=[C:11]([NH2:13])[NH:10][N:9]=2)[CH:5]=[CH:4][N:3]=1.[CH3:14]NN>>[Cl:1][C:2]1[CH:7]=[C:6]([C:8]2[CH:12]=[C:11]([NH2:13])[N:10]([CH3:14])[N:9]=2)[CH:5]=[CH:4][N:3]=1

参加物

反応物 2

HCID 6061Methylhydrazine

HCID 178507310HCID 178507310、化合物3 回

生成物 1

HCID 86664828HCID 86664828、化合物収率 89%

実験手順

This title intermediate was prepared starting from 18.B (3.10 g, 17.3 mmol) according the procedure described above for conversion of 18.B to 18.C, except that methylhydrazine (3.5 equiv.) was used. The crude product was purified by flash chromatography on silica gel using 0-8% MeOH/CH2Cl2 for elution to provide 23.A (3.44 g mg, 89%) as a brown solid.

後処理

customThe crude product was purified by flash chromatography on silica gel using 0-8% MeOH/CH2Cl2 for elution

出典と根拠

ORDレコード: ord-18456180be1243f0a8af25b68f19576c
出典データセット: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08785468B2

反応ノート

読み込み中…

参加物