HCID 86664828、化合物 → HCID 67497326、化合物
反応式
Cl[C:2]1[CH:7]=[C:6]([C:8]2[CH:12]=[C:11]([NH2:13])[N:10]([CH3:14])[N:9]=2)[CH:5]=[CH:4][N:3]=1.[NH2:15][C:16]1NN=C(C2C=CN=C(NC)C=2)C=1>>[NH2:13][C:11]1[N:10]([CH3:14])[N:9]=[C:8]([C:6]2[CH:5]=[CH:4][N:3]=[C:2]([NH:15][CH3:16])[CH:7]=2)[CH:12]=1参加物
3
実験手順
This title intermediate was prepared starting from 23.A (2.10 g, 10.0 mmol) according the procedure described above for conversion of 18.0 to 18.D. The crude product was purified by flash chromatography using 0-10% MeOH/CH2Cl2 for elution to provide 23.B as white solid (1.61 g, 79%).
後処理
- customThe crude product was purified by flash chromatography
- washfor elution
出典と根拠
- ORDレコード
- ord-71db85fd8d334e30b56879e7f0db2253
- 出典データセット
- uspto-grants-2014_07
- 特許番号
- US08785468B2
反応ノート
読み込み中…