Hydrochloric Acid → HCID 67497334、化合物
反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C@H:9]([NH:25]C(=O)OC(C)(C)C)[C:10]([NH:12][C:13]2[N:17]([CH3:18])[N:16]=[C:15]([C:19]3[CH:24]=[CH:23][N:22]=[CH:21][CH:20]=3)[CH:14]=2)=[O:11])=[CH:4][CH:3]=1.Cl>O1CCOCC1>[NH2:25][C@@H:9]([CH2:8][C:5]1[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=1)[C:10]([NH:12][C:13]1[N:17]([CH3:18])[N:16]=[C:15]([C:19]2[CH:24]=[CH:23][N:22]=[CH:21][CH:20]=2)[CH:14]=1)=[O:11]参加物
4
実験手順
To a 100 ml flask was added tert-butyl (S)-3-(4-fluorophenyl)-1-(1-methyl-3-(pyridin-4-yl)-1H-pyrazol-5-ylamino)-1-oxopropan-2-ylcarbamate 103.1.A (1.35 g, 3.07 mmole), 18 ml of 4N-hydrogen chloride solution in 1,4-dioxane and 9 ml of 1,4-dioxane. The reaction was stirred at room temperature for 2 hours at which time the solvent was removed by rotary evaporation. The residue was suspended in ethyl acetate, and washed successively with saturated sodium bicarbonate, water and brine. The organic layer was dried over anhydrous sodium sulfate, and concentrated in vacuo to give 103.1.B (905 mg, 87% yield) as colorless crystals.