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Acetaminophen → 2-Chloro-6-(4-acetamidophenyl-oxy)-pyrazine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetaminophen | HCID 1983 | — |
| 反応物 | 2,6-Dichloropyrazine | HCID 78504 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | 2-Chloro-6-(4-acetamidophenyl-oxy)-pyrazine | HCID 59343482 | 92% |
反応手順
Using Method DD with 2,6-dichloropyrazine (200 mg, 1.34 mmol) and 4-acetamidophenol (202 mg, 1.49 mmol), and crystallisation in AcOEt, the title compound was obtained (327 mg). Yield: 92%. 1H NMR (250 MHz, DMSO-d6) δ 2.12 (s, 3H, CH3—NH), 7.25 (d, 2H, Harom 3+5, J=8.9 Hz), 7.71 (d, 2H, Harom 2+6, J=8.9 Hz), 8.55 (s, 1H, HPz 5), 8.57 (s, 1H, HPz 3), 10.10 (s, 1H, NH). m/z: 264.0 [(M+H)+, calcd for C12H10ClN3O2 263.0].
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07737152B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-1021f49b714044e99d2cad1994e02d0f |
| 出典メモ | uspto-grants-2010_06 |