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3,4,5-Trimethoxyaniline → 6-(2-fluorophenoxy)-N-(3,4,5-trimethoxyphenyl)pyrazin-2-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3,4,5-Trimethoxyaniline | HCID 32285 | — |
| 反応物 | 2-Chloro-6-(2-fluorophenyl-oxy)-pyrazine | HCID 59343498 | — |
| 溶媒 | Cyclohexane | HCID 8078 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | 6-(2-fluorophenoxy)-N-(3,4,5-trimethoxyphenyl)pyrazin-2-amine | HCID 24879262 | 71% |
反応手順
Using Method EE with 2-chloro-6-(2-fluorophenyloxy)-pyrazine (200 mg, 0.89 mmol) and 3,4,5-trimethoxyaniline (196 mg, 1.07 mmol), and purification by column chromatography (AcOEt:cyclohexane, 1:1), the title compound was obtained (234 mg). Yield: 71%. 1H NMR (250 MHz, DMSO-d6) δ 3.42 (s, 6H, [CH3O]3+5), 3.54 (s, 3H, [CH3O]4), 6.69 (s, 2H, Harom2′+6′), 7.24-7.41 (m, 4H, Harom), 7.83 (s, 1H, HPz 5), 7.96 (s, 1H, HPz 3), 9.57 (s, 1H, NH).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07737152B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-df473a454960406bbfb2ce3c5998edea |
| 出典メモ | uspto-grants-2010_06 |