Benzenamine, 3-bromo-4-methyl- → (3-Bromo-4-methyl-phenyl)-[1-(4-chloro-3-methyl-phenyl)-propyl]-amine

HRID 1629704ノート

反応式

HRID 1629704 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=O)[CH2:9][CH3:10])=[CH:4][C:3]=1[CH3:12].[Br:13][C:14]1[CH:15]=[C:16]([CH:18]=[CH:19][C:20]=1[CH3:21])[NH2:17].[B][B][B][B][B][B][B][B][B][B]>CO>[Br:13][C:14]1[CH:15]=[C:16]([NH:17][CH:8]([C:5]2[CH:6]=[CH:7][C:2]([Cl:1])=[C:3]([CH3:12])[CH:4]=2)[CH2:9][CH3:10])[CH:18]=[CH:19][C:20]=1[CH3:21]

参加物

5

反応物 3

HCID 82187Benzenamine, 3-bromo-4-methyl-HCID 391041011-(4-Chloro-3-methylphenyl)propan-1-oneHCID 178419135HCID 178419135、化合物2 回

生成物 1

HCID 67343963(3-Bromo-4-methyl-phenyl)-[1-(4-chloro-3-methyl-phenyl)-propyl]-amine

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of INT 5 (3.00 g, 16.4 mmol) and 3-bromo-4-methylaniline (3.06 g, 16.4 mmol) in MeOH (164 mL) was added decaborane (1.00 g, 8.2 mmol). The reaction mixture was stirred at room temperature overnight. More decaborane (0.50 g, 4.1 mmol) was added. The mixture was stirred at 60° C. for 2 hours. The mixture was concentrated. The residue was purified by chromatography on silica gel (heptane/EtOAc) to afford INT 8.

後処理

  1. stirringThe mixture was stirred at 60° C. for 2 hours
  2. concentrationThe mixture was concentrated
  3. customThe residue was purified by chromatography on silica gel (heptane/EtOAc)
  4. customto afford INT 8

出典と根拠

ORDレコード
ord-ed2fbaee727e43b5aeaa740330c55434
出典データセット
uspto-grants-2014_07
特許番号
US08791100B2

反応ノート

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