Hydrochloric Acid → Methyl 3-methylazetidine-3-carboxylate hydrochloride

HRID 1629710ノート

反応式

HRID 1629710 の反応式
[CH3:1][O:2][C:3]([C:5]1([CH3:16])[CH2:8][N:7](C(OC(C)(C)C)=O)[CH2:6]1)=[O:4].[ClH:17]>C(Cl)Cl>[ClH:17].[CH3:1][O:2][C:3]([C:5]1([CH3:16])[CH2:8][NH:7][CH2:6]1)=[O:4]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 574158901-Tert-butyl 3-methyl 3-methylazetidine-1,3-dicarboxylate

生成物 1

HCID 67329141Methyl 3-methylazetidine-3-carboxylate hydrochloride

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of INT 13 (1.66 g, 7.24 mmol) in CH2Cl2 was added HCl (2.0 M in Et2O, 36.2 mL, 72.4 mmol). The reaction mixture was stirred at room temperature for 20 hours. The mixture was concentrated to afford INT 14.

後処理

  1. concentrationThe mixture was concentrated
  2. customto afford INT 14

出典と根拠

ORDレコード
ord-76244b54abf84904a71c0776b0fe435c
出典データセット
uspto-grants-2014_07
特許番号
US08791100B2

反応ノート

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