2-(1H-1,2,3-Triazol-1-yl)acetic acid hydrochloride → HCID 67009930、化合物
反応式
Cl.[N:2]1([CH2:7][C:8]([OH:10])=O)[CH:6]=[CH:5][N:4]=[N:3]1.[F:11][C:12]1[CH:40]=[CH:39][C:15]([O:16][C:17]2[CH:22]=[CH:21][C:20]([NH:23][C:24]([C@@H:26]3[CH2:30][C@@H:29]([CH2:31][C:32]4[CH:37]=[CH:36][C:35]([CH3:38])=[CH:34][CH:33]=4)[CH2:28][NH:27]3)=[O:25])=[CH:19][CH:18]=2)=[CH:14][CH:13]=1>>[N:2]1([CH2:7][C:8]([CH:28]2[NH:27][C@H:26]([C:24]([NH:23][C:20]3[CH:19]=[CH:18][C:17]([O:16][C:15]4[CH:39]=[CH:40][C:12]([F:11])=[CH:13][CH:14]=4)=[CH:22][CH:21]=3)=[O:25])[CH2:30][C@H:29]2[CH2:31][C:32]2[CH:33]=[CH:34][C:35]([CH3:38])=[CH:36][CH:37]=2)=[O:10])[CH:6]=[CH:5][N:4]=[N:3]1参加物
3
実験手順
Proceeding as in Example 1, but substituting 2-(1H-1,2,3-triazol-1-yl)acetic acid hydrochloride and (2S,4R)—N-(4-(4-fluorophenoxy)phenyl)-4-(4-methylbenzyl)pyrrolidine-2-carboxamide, gave Compound 3, (2S,4R)-5-(2-(1H-1,2,3-triazol-1-yl)acetyl)-N-(4-(4-fluorophenoxy)phenyl)-4-(4-methylbenzyl)pyrrolidine-2-carboxamide. 1H-NMR (400 MHz, CDCl3): σ 8.96 (br s, 1H), 7.77 (s, 1H), 7.74 (s, 1H), 7.42 (m, 2H), 7.13 (d, 2H), 7.08 (d, 2H), 7.03-6.98 (m, 2H), 6.94-6.87 (m, 4H), 5.27 (d, 1H), 5.13 (d, 1H), 4.76 (d, 1H), 3.66 (m, 1H), 3.26 (t, 1H), 3.02-2.85 (m, 2H), 2.66-2.57 (m, 2H), 2.33 (s, 3H), 1.76-1.68 (m, 1H); MS (EI) for C29H28FN5O3. found 514.1 (MH+).