Diethyl Ether → 2,5-Dichloro-4-methoxypyrimidine
反応式
[Cl:1][C:2]1[C:3](Cl)=[N:4][C:5]([Cl:8])=[N:6][CH:7]=1.[CH2:10]([O:12]CC)C.C[O-].[Na+]>CO>[Cl:8][C:5]1[N:4]=[C:3]([O:12][CH3:10])[C:2]([Cl:1])=[CH:7][N:6]=1参加物
5
反応条件
- 温度
- 0 °C
実験手順
To a 250 mL round bottom flask equipped with a stir bar was added 1 g 5-chloro-2,4-dichloro-pyrimidine, and 15 mL of diethyl ether. The mixture was cooled to 0° C. in an ice bath and then 1 equivalent of sodium methoxide in methanol (prepared from reacting 120 mg of sodium with 4 mL of methanol at room temperature) was slowly added. The reaction was stirred over night at room temperature and checked by LCMS. The white precipitate was filtered and the solid washed with cold methanol. After drying, 0.98 g of pure 2,5-dichloro-4-methoxypyrimidine was obtained and this material was used without further purification.
後処理
- customTo a 250 mL round bottom flask equipped with a stir bar
- filtrationThe white precipitate was filtered
- washthe solid washed with cold methanol
- customAfter drying
出典と根拠
- ORDレコード
- ord-87606e4e32654582b4d49afdfbb179d0
- 出典データセット
- uspto-grants-2014_07
- 特許番号
- US08791130B2
反応ノート
読み込み中…