Ethanol → 5-Iodo-4-(1-methylhydrazino)-2-methylthiopyrimidine
反応式
C(=O)([O-])[O-].[K+].[K+].C(O)C.Cl[C:11]1[C:16]([I:17])=[CH:15][N:14]=[C:13]([S:18][CH3:19])[N:12]=1.[CH3:20][NH:21][NH2:22]>O>[I:17][C:16]1[C:11]([N:21]([CH3:20])[NH2:22])=[N:12][C:13]([S:18][CH3:19])=[N:14][CH:15]=1参加物
6
実験手順
603 mg of potassium carbonate was added to ethanol (15 mL) solution of 1.25 g of 4-chloro-5-iodo-2-(methylthio)pyrimidine, and with cooling with ice, 0.28 mL of methylhydrazine was dropwise added thereto. This was stirred overnight at room temperature, then water was added thereto, and the precipitated crystal was taken out through filtration and dried to obtain 851 mg of the entitled compound as a white solid.
後処理
- additionwas dropwise added
- filtrationthe precipitated crystal was taken out through filtration
- customdried
出典と根拠
- ORDレコード
- ord-ffdef4ce37664b3fbc9c885ff0d452c5
- 出典データセット
- uspto-grants-2014_07
- 特許番号
- US08791125B2
反応ノート
読み込み中…