関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 2-Naphthalenesulfonic acid | HCID 8420 | — |
| 反応物 | 4,5-Dihydro-2-(methylthio)thiazole | HCID 88324 | — |
| 反応物 | 4-Chloro-2,3-dihydro-1H-isoindole | HCID 14795868 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | HCID 19691974 | HCID 19691974 | — |
反応手順
A mixture of 4-chloroisoindoline (700 mg), 2-methylthio-2-thiazoline (600 mg), and β-naphthylsulfonic acid (35 mg) was heated at 150° C. for 30 minutes. The product was cooled, dissolved in methylene chloride, washed with water, the organic layer dried over anhydrous potassium carbonate, filtered, and solvent removed from the filtrate under reduced pressure. The residue was chromatographed on silica gel packed in methylene chloride/2% methanol/ammonia, eluting with methylene chloride/2% methanol, to give 4-chloro-2-(thiazolin-2-yl)isoindoline, a compound of Formula (IA), m.p. 167°-169° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05726197 |
|---|
| 出典データセット | uspto-grants-1998_03 |
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| ORD ID | ord-0591013fd92545f5bf5092992c26919f |
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| 出典メモ | uspto-grants-1998_03 |
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