Hydrochloric Acid → HCID 66836366、化合物
反応式
[ClH:1].C(OC([NH:9][C@@H:10]([CH3:45])[C:11]([O:13][CH2:14][C:15]1[CH:20]=[C:19]([F:21])[C:18]([F:22])=[CH:17][C:16]=1[C:23]1[CH:24]=[C:25]2[C:30](=[CH:31][CH:32]=1)[N:29]=[C:28]([NH2:33])[N:27]=[C:26]2[C:34]([N:36]1[CH2:44][C:43]2[C:38](=[CH:39][CH:40]=[CH:41][CH:42]=2)[CH2:37]1)=[O:35])=[O:12])=O)(C)(C)C>O1CCOCC1.ClCCl>[ClH:1].[ClH:1].[NH2:9][C@@H:10]([CH3:45])[C:11]([O:13][CH2:14][C:15]1[CH:20]=[C:19]([F:21])[C:18]([F:22])=[CH:17][C:16]=1[C:23]1[CH:24]=[C:25]2[C:30](=[CH:31][CH:32]=1)[N:29]=[C:28]([NH2:33])[N:27]=[C:26]2[C:34]([N:36]1[CH2:44][C:43]2[C:38](=[CH:39][CH:40]=[CH:41][CH:42]=2)[CH2:37]1)=[O:35])=[O:12]参加物
5
反応条件
- 温度
- 25 °C
実験手順
911 μl of 4N HCl in dioxane are added to 220 mg of 2-[2-amino-4-(1,3-dihydroisoindole-2-carbonyl)quinazolin-6-yl]-4,5-difluorobenzyl (S)-2-tert-butoxycarbonylaminopropionate in 4 ml of dichloromethane with ice-cooling. The mixture is subsequently stirred at 25° C. for a further 1 h, the precipitate is filtered off with suction and washed with 4 ml of dichloromethane. The residue is recrystallised from ethanol.